Entdeckung eines Kometen 1905 b

Experimente zur Entdeckung von P2P Botnetzen

Botnets, which are used to perform various malicious activities, have become a major threat in recent years. Spamming, phishing, stealing sensitive information, conducting distributed denial of service (DDoS) attacks, scanning to find more hosts to compromise using malware are the goals of many botnets, sometimes of low-profile botnets such as the Nugache botnet [1] which used a peer-to-peer (P...

Wege zur Entdeckung von Communities in Folksonomies

Ein wichtiger Baustein des neu entdeckten World Wide Web – des ”Web 2.0“ – stellen Folksonomies dar. In diesen Systemen können Benutzer gemeinsam Ressourcen verwalten und mit Schlagwörtern versehen. Die dadurch entstehenden begrifflichen Strukturen stellen ein interessantes Forschungsfeld dar. Dieser Artikel untersucht Ansätze und Wege zur Entdeckung und Strukturierung von Nutzergruppen (”Commu...

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Dmd065763 1905..1916

Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

Phoebus A. Levene, 1905